Stress Lowers Testosterone - Clinical Research
New clinical research shows how stress-induced cortisol can decrease testosterone—especially in men with metabolic conditions like Type 2 diabetes.
Most people know chronic stress can interfere with sleep, energy, and mental clarity. But a growing body of research now reveals something equally important: stress may also disrupt hormonal balance—especially testosterone, a hormone critical for men’s health, strength, mood, and metabolic vitality.
A 2023 peer-reviewed study uncovered a clear biological pathway showing how stress-induced cortisol can suppress testosterone production. This effect was especially notable in men with metabolic challenges such as Type 2 Diabetes Mellitus (T2DM).
Understanding this connection is essential—not only for mood and energy—but for long-term metabolic health, physical performance, and overall well-being.
Table of Content
What the Study Found: How Stress Impacts Testosterone
The 2023 clinical study revealed a clear and measurable relationship between stress, cortisol, and testosterone regulation—especially in men with metabolic challenges like Type 2 diabetes.
Higher Stress = Higher Cortisol
- Men with T2DM showed significantly higher cortisol—the body’s primary stress hormone—compared to healthy controls.
- Short-term cortisol spikes are expected.
- But chronically elevated cortisol disrupts hormone-producing pathways, including those involved in testosterone synthesis, signaling, and availability.
Higher Cortisol = Lower Testosterone
- The researchers found a strong negative correlation: As cortisol rises, testosterone drops.
- Men in the high-cortisol group had markedly lower testosterone levels, even when accounting for age, BMI, and metabolic status. This set the stage for the deeper biological analysis explaining why this happens.
Stress-Activated Genes (Triggered by High Cortisol)
When cortisol remains elevated, certain genes become unusually active—shifting the body into a stress-dominant hormonal mode. These genes directly affect testosterone pathways.
-
FKBP5: A stress-response gene that becomes highly active under chronic cortisol exposure.
Elevated FKBP5 disrupts HPA-axis stability and hormone signaling—making it harder for the body to maintain healthy testosterone production. -
CYP17: A gene involved in steroid hormone synthesis.
When cortisol activates CYP17, the body may redirect hormone-building resources away from testosterone, contributing to decreased output.
Testosterone-Regulating Genes Suppressed by Stress
As stress-activated genes turn on, several testosterone-supporting genes turn off.
-
SHBG (Sex Hormone Binding Globulin): Controls the protein that binds testosterone.
Reduced SHBG expression = less free, active testosterone available to cells. -
AR (Androgen Receptor): Produces the receptor testosterone binds to.
Lower AR expression reduces the body’s sensitivity to testosterone, even if total levels appear normal. -
TCF4 / TCF8: Genes involved in hormone regulation and cellular development.
When suppressed, the pathways supporting normal testosterone production become less efficient. - ATRX: Supports DNA stability and healthy function of hormone-producing cells.Reduced ATRX expression impairs the body’s ability to regulate testosterone synthesis and balance.
The Biological Pathway
The study mapped out the sequence of events that link stress to declining testosterone:
- Stress increases cortisol
- Cortisol activates the Gαs–cAMP/PKA pathway
- Stress-response genes (FKBP5, CYP17) switch ON
- Testosterone-regulating genes (SHBG, AR, TCF4/TCF8, ATRX) switch OFF
- Testosterone production and signaling drop
The Takeaway: Why This Matters
This biological chain explains why testosterone is often lower in men experiencing:
- Chronic stress
- Burnout
- Poor sleep
- Overtraining
- Metabolic strain
- Long-term psychological pressure
Stress doesn’t just affect your mood— it alters your genetics, hormone pathways, and long-term testosterone health.
Missing Link: Why Testosterone Boosters Alone Aren’t Enough
This is where many men go wrong.
Men commonly turn to:
- Testosterone Replacement Therapy (TRT)
Testosterone boosting supplements
Gym routines
Diet changes
But if cortisol remains elevated, the body cannot efficiently produce or utilize testosterone, even with supplementation.
To truly support hormonal balance, men must also support:
Healthy cortisol regulation
Stress recovery
Sleep quality
Adaptogenic support of the HPA axis
Gut–brain axis health
This is where stress-support supplements play an important role by help reduce cortisol, promote calm focus, and support hormone-friendly stress resilience.
StressControl by Answers Wellness is formulated with clinically validated natural ingredients that work together to help lower cortisol, stabilize the nervous system, and support calm, focused energy—especially on your most overwhelming days.
✅ Reduces Stress: Lowers cortisol and calms the nervous system for lasting stress relief.
✅ Boosts Energy: Helps fight fatigue and sustain natural, balanced energy throughout the day.
✅ Improves Memory & Focus: Lion’s Mane and Phosphatidylserine support cognitive function, mental clarity, and recall.
✅ Enhances Sleep Quality: Lemon Balm and L-Theanine promote deeper, more restful sleep.
✅ Supports Overall Well-Being: Adaptogens, antioxidants, and a time-release formula provide steady, natural support for mind-body balance.
StressControl ingredients are verified through rigorous third-party testing and certification, ensuring uncompromising quality in every dose.
Choosing Natural Supplement |
Stress Control by Answers Wellness |
Many Other Stress Supplements |
Clinically Researched, Science-Backed Ingredients |
Includes ingredients at clinically validated potency levels (e.g., L-Theanine, Lion’s Mane, Holy Basil, Phosphatidylserine) proven to reduce cortisol, calm mood, sharpen focus, and improve sleep. |
Often rely on generic or under-dosed blends with little scientific validation, leading to weak or inconsistent results. |
Traceable & Certified Sourcing |
Every ingredient is traceable to origin and certified authentic, ensuring purity, transparency, and sustainable practices. |
Sourcing is often unclear or unverified, increasing risks of adulteration, fillers, or hidden contaminants. |
Manufactured to the Highest Standards |
Produced in the USA at an NSF-certified GMP facility, meeting strict pharmaceutical-grade safety and quality standards. |
Many only claim GMP compliance—with studies showing up to 80% fail to follow proper standards. |
Comprehensive Quality Testing |
Every batch is third-party tested for identity, purity, potency, heavy metals, and microbiology. Each comes with a Certificate of Analysis (COA) for full transparency. |
Limited or no independent testing. COAs rarely provided, leaving consumers in the dark about safety or potency. |
Certifications That Matter |
Backed by meaningful certifications: 100% Natural, Non-GMO, Lab-Tested, GMP Certified, and features a unique Extended Time-Release Formula for all-day calm. |
Often lack third-party certifications. Products may contain synthetic fillers, GMOs, or provide only short-term relief. |
Ways Men Can Support Healthy Testosterone by Managing Stress
Prioritize restorative sleep: Deep sleep is where testosterone repair and production peak.
Support cortisol balance naturally Adaptogenic herbs like Holy Basil, Reishi, and Ashwagandha are clinically shown to support cortisol regulation.
(As featured in StressControl, with clinically validated ingredients )
Practice short, daily stress-reduction habits: Slow breathing, Short breaks during work, Light walks, Mindfulness practices (Even 5–10 minutes daily can down-shift stress hormones.)
Reduce stimulants: Caffeine spikes can amplify cortisol output, especially when consumed during stress.
Strengthen gut health: A balanced gut supports the gut-brain axis, which influences cortisol and mood.
Maintain metabolic health: Balanced blood sugar and healthy weight strongly influence testosterone and cortisol dynamics.
Summary: Stress Reduces Testosterone — Research Proves It
The science is clear: long-term stress doesn’t just feel overwhelming—it directly reduces testosterone by disrupting the body’s hormonal signaling pathways.
When cortisol stays elevated, it gradually erodes the hormones responsible for motivation, strength, mood stability, and overall vitality.
Protecting your well-being means protecting your testosterone. A strong stress-management strategy should include the fundamentals: a consistent sleep routine, regular exercise with proper recovery, a nutrient-dense diet, limiting stimulants, and reducing chronic psychological stressors whenever possible.
But lifestyle alone isn’t always enough.
Many men support testosterone levels with natural testosterone-boosting supplements or, under medical supervision, testosterone replacement therapy (TRT) to help restore hormonal balance, improve energy, and support long-term health. These approaches can absolutely enhance testosterone levels when used responsibly.
However, even with a healthy lifestyle, targeted supplements, or TRT, unmanaged stress can work against you. Research consistently shows that chronically elevated cortisol can blunt the benefits of natural testosterone-support ingredients—and even reduce the effectiveness of TRT—by interfering with the hormonal pathways involved in testosterone production and signaling.
In other words, you can be doing everything “right,” and stress can still pull your levels in the wrong direction.
That’s why managing stress isn’t optional—it’s foundational. Incorporating a natural, research-backed stress-support supplement, such as those formulated with clinically validated ingredients to help keep cortisol in a healthy range, can provide crucial protection against the hormonal decline triggered by long-term stress .
With the right support, you can stay energized, balanced, and resilient—both mentally and hormonally.
Study Limitations
The study has several limitations: it included a modest sample size, evaluated only men, and focused specifically on individuals with Type 2 Diabetes Mellitus (T2DM). Its cross-sectional design captures only a single point in time, and the genetic findings show correlation rather than proven causation.
Even so, the research provides valuable insight into how elevated stress and cortisol may suppress testosterone production.
Source: Stress-Induced Cortisol Release Depresses the Secretion of Testosterone in Patients With Type 2 Diabetes Mellitus
https://pubmed.ncbi.nlm.nih.gov/36636127
The Author: Samir Patel
With over 22 years of expertise in nutrition science, Samir Patel bridges traditional wellness wisdom with modern clinical research. He advises the science-based formulation of our natural supplements in collaboration with our manufacturing partners. At Answers Wellness, Samir leads product development and consumer education—delivering clear, evidence-based guidance that empowers people to build sustainable, long-term wellness.
Nature Provides, Science Answers
At Answers Wellness , we believe in the power of nature combined with the science of wellness. Our commitment is to deliver high-quality, nature-based supplements that support holistic well-being. Whether you're seeking stress-reducing or gut health supplements, we provide scientifically-formulated solutions for better health.
Explore our science-formulated natural supplements at Answers Wellness.
Explore StressControl by Answers Wellness
FAQ
What is Purpose of Answers Wellness?
Answers Wellness is committed to empowering individuals to achieve balanced, resilient health through premium science-backed natural supplements and comprehensive wellness education. Guided by our belief that “Nature Provides, Science Answers,” we blend the wisdom of nature with rigorous scientific research to deliver high-quality, nature-based products and practical guidance that support holistic mind-body wellness.
We specialize in natural supplements for stress relief, gut health and holistic wellness.
What is Mission of Answers Wellness?
Support lasting health and wellness by offering high-quality, clinically researched natural supplements and evidence-based education, promoting sustainable holistic well-being.
We specialize in natural supplements for stress relief, gut health and holistic wellness.
What is unique about Answers Wellness supplements?
Clinically Researched, Science-Backed Ingredients – Every formula is crafted with natural, traceable ingredients that are clinically studied for proven safety and effectiveness.
Traceable and Certified Sourcing – We ensure complete ingredient transparency origin and authenticity, so you know exactly where your wellness support comes from.
Comprehensive Quality Testing — Every formula undergoes independent third-party testing for identity, purity, potency, microbiology, and heavy metals. To ensure complete transparency, each batch is backed by a Certificate of Analysis (COA), giving you visible proof of safety, quality, and effectiveness.
Manufactured to the Highest Standards – Produced in NSF GMP-certified facilities, meeting strict pharmaceutical-grade quality standards that most brands only claim.
Certifications That Matter – Our supplements are 100% natural, non-GMO, lab-tested, and GMP-certified—delivering results you can trust with integrity and care.
What are the benefits of taking a natutal holistic stress supplement versus a prescription drug?
Natural, holistic supplements can be as effective, if not more effective, than pharmaceutical drugs for men's health as well as women's.
Natural supplements are effective because they contain natural ingredients, take a whole-body approach to health, offer individualized treatment options, and have less risk of dependency or addiction compared to pharmaceutical drugs. Natural supplements provide gentler alternatives with fewer side effects while still providing powerful therapeutic benefits for various health conditions, including reducing stress. Be sure to consult with a registered dietitian.
Why is StressControl superior in natural stress relief supplements?
When it comes to natural stress relief supplements, not all products are created equal. StressControl by Answers Wellness stands apart with a rare combination of science, transparency, and uncompromising quality—delivering results you can trust.
1. Clinically Researched, Science-Backed Ingredients
Unlike many natural supplements for stress that rely on generic or under-dosed blends, StressControl includes ingredients at clinically validated potency levels. This ensures you actually feel the benefits that research confirms—lower cortisol, calmer mood, sharper focus, and better sleep. Ingredients like L-Theanine, Lion’s Mane Mushroom, Holy Basil, and Phosphatidylserine work together synergistically, delivering results you can trust.
2. Traceable and Certified Sourcing
Every ingredient in StressControl is traceable back to its source and certified for authenticity, protecting you from hidden fillers, adulteration, or contaminants. Unlike many supplements that offer little transparency, StressControl ensures you know exactly what you’re putting into your body—ethically and sustainably.
3. Comprehensive Quality Testing
Each batch undergoes rigorous third-party testing for identity, purity, potency, microbiology, and heavy metals. To guarantee transparency, every batch is accompanied by a Certificate of Analysis (COA)—so you have visible proof of safety and effectiveness, not just claims.
4. Manufactured to the Highest Standards
StressControl is produced in an NSF-certified GMP facility in the USA, where pharmaceutical-grade quality-control standards safeguard against contamination and inconsistency. While many brands claim GMP compliance, studies show up to 80% fail. With StressControl, compliance is verified—not just promised.
5. Certifications That Matter
StressControl is more than a natural stress supplement—it’s certified 100% natural, non-GMO, and lab-tested for identity, purity, and potency. It is manufactured under strict Good Manufacturing Practices (GMP) and features a unique Extended-Time-Release Formula, ensuring calm, focus, and balance that lasts all day.
- 100% Natural – No synthetic additives or harmful preservatives.
- Lab-Tested – Independent testing for identity, purity, and potency.
- GMP Certified – Manufactured under strict quality standards.
- Non-GMO – Free from genetically modified ingredients.
- Extended Time-Release Formula – Slow, steady nutrient delivery for all-day stress relief.
The Result: StressControl by Answers Wellness is one of the most effective, transparent, and trustworthy natural stress relief supplements available today—backed by science, proven by testing, and certified for your safety.
What are the benefits of StressControl?
Stress Relief: StressControl is formulated with clinically researched ingredients like L-Theanine, Holy Basil, and Lemon Balm, shown in human studies to lower cortisol levels and calm the nervous system. This helps you feel more relaxed and in control, even in high-pressure situations. Resulting in long-lasting stress relief. Made with traceable, certified ingredients and backed by clinical research, StressControl is carefully tested for purity, potency, and safety in a GMP-certified facility.*
Increased Energy Levels: Many stress supplements cause drowsiness or depend on caffeine. StressControl is different. Our unique blend of natural ingredients with Reishi Mushroom and L-Tyrosine, promotes steady energy, focus, and endurance. Clinical studies confirm their role in balancing stress hormones, fueling neurotransmitter production, and improving mental performance—so you get sustained calm energy without crashes.*
Improved Memory: Stress can cloud your mind, but StressControl helps keep you sharp. Featuring Lion’s Mane Mushroom, clinically shown to boost nerve growth factor, and Phosphatidylserine, validated to enhance memory recall and reduce stress-induced cortisol spikes, StressControl is more than a stress supplement—it’s a natural nootropic. Together, these ingredients improve memory, concentration, and long-term brain health, making it the best natural stress supplement for focus and clarity.*
Better Sleep: Quality sleep is essential for recovery and resilience. StressControl combines L-Theanine and Lemon Balm, both backed by research for their ability to promote alpha brain waves, reduce nighttime stress, and improve sleep depth. The result? Easier sleep onset, deeper rest, and refreshed mornings—making StressControl a top natural sleep and stress supplement for restoring mind-body balance.*
Related Articles
What is Purpose of Answers Wellness?
Answers Wellness is committed to empowering individuals to achieve balanced, resilient health through premium science-backed natural supplements and comprehensive wellness education. Guided by our belief that “Nature Provides, Science Answers,” we blend the wisdom of nature with rigorous scientific research to deliver high-quality, nature-based products and practical guidance that support holistic mind-body wellness.
We specialize in natural supplements for stress relief, gut health and holistic wellness.
What is Mission of Answers Wellness?
Support lasting health and wellness by offering high-quality, clinically researched natural supplements and evidence-based education, promoting sustainable holistic well-being.
We specialize in natural supplements for stress relief, gut health and holistic wellness.
What is unique about Answers Wellness supplements?
Clinically Researched, Science-Backed Ingredients – Every formula is crafted with natural, traceable ingredients that are clinically studied for proven safety and effectiveness.
Traceable and Certified Sourcing – We ensure complete ingredient transparency origin and authenticity, so you know exactly where your wellness support comes from.
Comprehensive Quality Testing — Every formula undergoes independent third-party testing for identity, purity, potency, microbiology, and heavy metals. To ensure complete transparency, each batch is backed by a Certificate of Analysis (COA), giving you visible proof of safety, quality, and effectiveness.
Manufactured to the Highest Standards – Produced in NSF GMP-certified facilities, meeting strict pharmaceutical-grade quality standards that most brands only claim.
Certifications That Matter – Our supplements are 100% natural, non-GMO, lab-tested, and GMP-certified—delivering results you can trust with integrity and care.
What are the benefits of taking a natutal holistic stress supplement versus a prescription drug?
Natural, holistic supplements can be as effective, if not more effective, than pharmaceutical drugs for men's health as well as women's.
Natural supplements are effective because they contain natural ingredients, take a whole-body approach to health, offer individualized treatment options, and have less risk of dependency or addiction compared to pharmaceutical drugs. Natural supplements provide gentler alternatives with fewer side effects while still providing powerful therapeutic benefits for various health conditions, including reducing stress. Be sure to consult with a registered dietitian.
Why is StressControl superior in natural stress relief supplements?
When it comes to natural stress relief supplements, not all products are created equal. StressControl by Answers Wellness stands apart with a rare combination of science, transparency, and uncompromising quality—delivering results you can trust.
1. Clinically Researched, Science-Backed Ingredients
Unlike many natural supplements for stress that rely on generic or under-dosed blends, StressControl includes ingredients at clinically validated potency levels. This ensures you actually feel the benefits that research confirms—lower cortisol, calmer mood, sharper focus, and better sleep. Ingredients like L-Theanine, Lion’s Mane Mushroom, Holy Basil, and Phosphatidylserine work together synergistically, delivering results you can trust.
2. Traceable and Certified Sourcing
Every ingredient in StressControl is traceable back to its source and certified for authenticity, protecting you from hidden fillers, adulteration, or contaminants. Unlike many supplements that offer little transparency, StressControl ensures you know exactly what you’re putting into your body—ethically and sustainably.
3. Comprehensive Quality Testing
Each batch undergoes rigorous third-party testing for identity, purity, potency, microbiology, and heavy metals. To guarantee transparency, every batch is accompanied by a Certificate of Analysis (COA)—so you have visible proof of safety and effectiveness, not just claims.
4. Manufactured to the Highest Standards
StressControl is produced in an NSF-certified GMP facility in the USA, where pharmaceutical-grade quality-control standards safeguard against contamination and inconsistency. While many brands claim GMP compliance, studies show up to 80% fail. With StressControl, compliance is verified—not just promised.
5. Certifications That Matter
StressControl is more than a natural stress supplement—it’s certified 100% natural, non-GMO, and lab-tested for identity, purity, and potency. It is manufactured under strict Good Manufacturing Practices (GMP) and features a unique Extended-Time-Release Formula, ensuring calm, focus, and balance that lasts all day.
- 100% Natural – No synthetic additives or harmful preservatives.
- Lab-Tested – Independent testing for identity, purity, and potency.
- GMP Certified – Manufactured under strict quality standards.
- Non-GMO – Free from genetically modified ingredients.
- Extended Time-Release Formula – Slow, steady nutrient delivery for all-day stress relief.
The Result: StressControl by Answers Wellness is one of the most effective, transparent, and trustworthy natural stress relief supplements available today—backed by science, proven by testing, and certified for your safety.